Ahead of City's trip, the Brazil worldwide said: "There's always a first time in the life, no? He played such an important part in our run to the World Cup semi-final, on the way to the Nations League and then had a really hard period at the end of last season and beginning of this with injuries", Southgate said.
After nearly 18 months of treatment in the Republic of Ireland, Cox moved to a specialist neurological facility in the north of England for a 12-week rehabilitation programme, focusing on developing his speech and movement.
The champions have also flagged up a social media post asking Reds fans to line the potential route of City's team coach.
"Hopefully it will be an incredible game and the same that happened two seasons ago won't happen".
"Something like this should not happen in general in life and it should not happen around a football game as well". I don't know when [he will be]. Clearly there's always competition for places at a club like City and if you can establish yourself there, then you're in a good place to be in good form when you come with us.
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In the summer, he said, Liverpool didn't make signings because the players who would improve a team that took 97 Premier League points and won the Champions League are too expensive.
It is a match between arguably the two best teams on the planet right now.
Meanwhile, Klopp reassured City they should have no concerns about their arrival at Anfield. City are concerned their coach could be attacked by Liverpool fans, as it was in April past year before their Champions League quarter-final tie when bottles, cans and flares were thrown.
City manager Pep Guardiola said the police were aware the last time their bus was attacked and hoped there would not be a repeat.
"We all didn't throw a bottle, but it was one of us".
Liverpool manager Juergen Klopp said it was everyone's responsibility to ensure that it does not happen again.
"We will do everything to make sure it doesn't happen again".