They had lost quarterback Jimmy Garoppolo to a season-ending ACL tear about a month prior, and although the 49ers had kept the score close for the first three losses following that injury, the Rams had completely blown the doors off for that fourth defeat.
This is significant as today, Rams head coach Sean McVay told reporters that Gurley is now day-to-day with a quad injury and didn't practice today. The Rams will defer to Gurley whether he's ready to go.
Gurley has rushed for 270 yards and five touchdowns on 64 carries five games into the season. Gurley, who has dealt with knee issues for quite some time, is now doubtful with a quad injury.More news: Alexei Leonov, first person to walk in space, dies at 85
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Here are the biggest causes for concern facing Los Angeles this weekend as Sean McVay's team takes on one of its biggest rivals.
On the Rams side, both running back Todd Gurley and cornerback Aqib Talib didn't practice for the second-straight day.
Though he has been healthy for all five games this season, Gurley has seen his workload cut dramatically thus far in 2019 relative to 2018.