The prince then has to inform Sheeran the video is not for the fictional "Gingers Unite" charity - it's for World Mental Health Day.
In the brief footage, lasting just ten seconds, Sheeran approaches a door, rings a doorbell, which plays God Save The Queen, to be greeted by Harry, who says: "Hello mate".
Check out the full teaser of what's happening below! I'm going to go and film a thing with Prince Harry.
Despite its amusing start, the video ends on a serious note as the Duke of Sussex asks viewers to try and look out for those who "may suffer in silence". When the pair sit down to discuss their collaboration, Prince Harry explains that Sheeran has the right "skill set" to create a song to help fight the problem.
He added: "People just don't understand what it's like for people like us".More news: Zuckerberg to testify in US Congress on Facebook digital currency
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The video starts with an enthusiastic Sheeran getting his beard trimmed, and telling the camera, "Really excited today".
In another fun twist, the video is believed to have been shot at the house of Prince Harry's cousin, Princess Eugenie. I just feel like it's time that we stood up and said, you know, 'We're not going to take this anymore. "I think people all over the world are suffering". More at: www.mentallyhealthyschools.org.uk In May this year The Duke and Duchess of Cambridge and The Duke and Duchess of Sussex launched Shout, a free, 24/7 text messaging service where people can Text "Shout" to 85258 if they are experiencing mental health challenges.
"There's no need to suffer in silence, share how you're feeling, ask how someone is doing and listen for the answer".
It finishes with a black screen with the words: "Tomorrow 10th October".
The Instagram post featuring the video tagged a variety of mental health-focused organizations, including Heads Together - an organization in which Prince William and Kate Middleton are also heavily involved - the Mental Health Foundation, YoungMinds U.K. and many more.
"We're all in this together".