A formal announcement about Dombrowski's removal is expected Monday, according to a tweet from MLB.com's Red Sox reporter, Ian Browne.
"Appreciative of my time here", Dombrowski said.
The move comes nearly immediately after Boston dropped the third game of a four-game set against the New York Yankees on Sunday night.
Ferreira is in her 21st season with the Red Sox organization, having previously served in various roles in the baseball operations department.
"This is a guy that gave me a chance to come here and be a big league manager", Alex Cora said Sunday night.
He was replaced by Ben Cherington, and in 2013 the Red Sox won their third world championship in 10 seasons. Dombrowski, 63, was hired in August 2015 and keyed the acquisitions of pitchers Chris Sale (via trade), David Price (free agency) and slugger J.D. Martinez. We'll talk about it tomorrow. It's just embarrassing enough that they had to do it at midnight on a Sunday during the season, and never bother to explain it publicly.More news: Apple unveils cheaper iPhones to combat declining phone sales
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Though many key parts of last year's World Series victor were in the organization before Dombrowski arrived, he supplemented them well.
"You take lots of guilt with you as a player because you're the one that can make or break things and that's the part that hurts me".
It's unclear if Ferreira (or any of the other top-ranking Red Sox executives) will have the opportunity to hold Dombrowski's old post for the long haul.
The Red Sox followed with three straight AL East titles - a first in franchise history, winning a club-record 108 games last season and their fourth World Series since 2004.
Romero has worked 14 seasons with the Red Sox and was named assistant general manager in November. While Dombrowski stood pat at the trade deadline, with a wild-card berth still in reach, the club went on an eight-game losing streak.