Nick Bosa, Jason Verrett Undergoing MRIs

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Lynch said Bosa nearly certainly will miss all of the 49ers' preseason games, which begins Saturday night with their opener against the Dallas Cowboys. Head coach Kyle Shanahan expected Bosa, the 2019 second overall pick, to be "alright" but did not have comment on Verrett.

Appearing on KNBR radio on Thursday, 49ers general manager John Lynch said rookie defensive end Nick Bosa suffered a "significant" ankle sprain during a sloppy Wednesday practice and would be out at least through the month of August.

Shanahan said the goal is to have Bosa available for the 49ers' regular-season opener against the Tampa Bay Buccaneers, but the team will be smart with the rookie's recovery. He doesn't have a full-blown one, but it has some components of that.

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Bosa has now sustained two injuries in 12 National Football League practices. The 49ers haven't had much of a pass-rush the past few years, and they're counting on Bosa to help jumpstart it. On Wednesday, in the 10th practice of training camp, Bosa was injured when he caught up in a pile on a running play.

It will be a surprise to see Bosa play in the preseason following this injury, which opens up playing time for fellow defensive linemen Ronald Blair and Kentavius Street. Bosa also suffered a torn ACL in high school.

Shanahan said Bosa was lucky to avoid a season-ending knee injury when a 300-pound-plus teammate landed on his lower leg. [Wednesday], he had a big human being fall on his leg while he was engaged with someone else. Injuries hampered him throughout his time as a Buckeye, including a core muscle injury that limited him to only three games in his final season on campus. "And trust Nick. We'll see where that goes".

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