Mixed doubles is not usually at the top of any Wimbledon player's list of priorities but it is different for Murray. It's always hard to tell as you only have mixed doubles at the Grand Slams, so nobody really get a chance to specialise in it or play it a lot.
"I wouldn't be here if it wasn't for her - I told her she was so inspiring and I've always wanted to tell her that but I've never had the guts to before".
"It [would] be a positive thing for tennis, if more guys were playing doubles", he said.
The eye-catching team of British star Murray and American Williams boast impeccable singles credentials but have plenty to prove as a partnership and will begin with a clash against Germany's Andreas Mies and American-born Chilean Alexa Guarachi. "I think above all that is just fantastic".
Finland's Henri Kontinen and Briton Heather Watson won the mixed doubles at Wimbledon in 2016 and were runners-up a year later.
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The Scot underwent a hip resurfacing operation after the Australian Open in an effort to extend his career - initially, he planned on retiring at Wimbledon - and duly returned in doubles at Queens in London last month.
When Williams appeared at her post-match news conference after a first-round victory in singles Tuesday - which happened before the announcement that she'd play with Murray - she was greeted by plenty of questions about the possibility.
Jamie Murray, a two-time doubles major victor, has four mixed crowns. He really speaks up about women's issues no matter what. Up 5-3 and serving for the match, Serena had the chance to put Gatto-Monticone, a first-time qualifier, away, but the 31-year-old Italian fought back.
Oh, and Williams has won 14 Grand Slam doubles titles with massive sister Venus.
As a serial victor of grand slams, Davis Cups and Olympic gold medals, Andy Murray has done nearly everything there is to do in the sport of tennis.
Murray also plays men's doubles Thursday with Frenchman Pierre Hugues Herbert.