"The communities and health workers on the front line of this outbreak urgently need more support and resources from the global community to prevent this crisis from worsening inside the country and from spreading across borders".
In his resignation letter, health minister Oly Illunga says in a war - which is what the fight against EBOLA has become - it creates confusion having several centres of decision making.
According to DRC's health ministry, the Ebola outbreak has killed more than 1,700 people - more than two-thirds of those who contracted it - since it emerged in the country's eastern North Kivu and Ituri provinces last August.
"No country should close its borders or place any restrictions on travel and trade, including general quarantine of travelers from the Ebola-affected countries, now the DRC", the joint AU-WHO statement read.
He mentioned the present vaccine was the only one with clinically proven effectiveness.
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Though the disease has yet to spread beyond the DRC, its risk of doing so is high, especially as cases have begun to crop up in Goma, near the border with Rwanda.
In a release issued Friday, the Ministry said the term Public Health Emergency of International Concern is defined in the International Health Regulations (IHR) (2005) as an extraordinary event which is determined: to constitute a public health risk to other States through the international spread of disease; and to potentially require a coordinated international response.
This is not the first time an Ebola epidemic would be transmitted across borders. The United States is the largest single country donor to the Ebola response, and remains committed to helping the people affected by this outbreak.
It also affected Nigeria when a passenger from Liberia "imported" the disease into the country.
While the vaccine is in fact 97% effective, it is important to note that not everybody is vaccinated.
The response to the most recent outbreak has been complicated by sporadic assaults on well-being staff, and conspiracy theories concerning the current vaccine.
The AU, which had previously deployed the AVoHC in West Africa to respond to the outbreak back in 2014 to 2015, said that the AVoHC "will be very useful in the current outbreak".