Video shows U.S. Coast Guard Cutter Munro members intercept the submarine-type vessel.
Crew members onboard one of the vessels can be heard shouting at those inside the submersible as it approaches.
Before the sub was able to slip underwater, three commandos from US Coast Guard Cutter Munro (WMSL 755) jumped on the moving vessel.
The cutter then launched a helicopter beyond the line of sight of the submersible, and directed the two smaller boats to its location. Boarding them can be "hairy", he said - smugglers can be armed, and when caught, they typically open a valve to quickly fill the vessel with water, sending all the drugs and evidence to the ocean floor.
"It's moving pretty quickly and it's a high-speed evolution at sea which is inherently risky", Masson told Fox News, referencing the video. Photos also were released of the Coast Guard sinking drug boats.More news: Why Donald Trump bullying the Fed could influence Australian mortgage rates - PM
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"Make no mistake about it, Coasties, your courageous service is saving American lives", Vice President Mike Pence said at an event in San Diego overnight.
"These two issues are linked", he said.
The officers then open the hatch door where they apprehend a suspected drug smuggler inside and tell him to get down on the floor.
"Numerous U.S. agencies from the Departments of Defense, Justice and Homeland Security cooperated in the effort to combat transnational organized crime", the Coast Guard statement explains.
Once the Coast Guard seized the drugs from these vessels, some were deemed unworthy of towing back to shore due to flooding in engine compartments and a lack of sufficient tow points.