"We'll be severely affected as they won't come anymore", Miguel Angel Morales, the owner of private restaurant "La Moneda Cubana", told Xinhua.
Mayor Kriseman and his family are among the nearly 800,000 bookings scheduled for Cuban cruise destinations that have been blocked by the new sanctions, according to the Cruise Lines International Association.
Cubans who have welcomed and benefited from such visits as part of a rapproachment with the United States under Barack Obama in 2015 and 2016 watched sadly as the Empress of the Seas left the island.
"Our tour guide, when we took the classic auto tour, he was so friendly - spoke wonderful English and was a Cuban native", Booth said. Some found out while walking around Havana during the abbreviated port call.
Americans have not been able to travel freely to Cuba but were able to do so as part of organized travel groups.
Other small business owners in the area, like 24-year-old Gillian Sosa, who sells crafts and souvenirs, believe Washington's regulations could also scare off tourists from other nations.
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"Trump's new measures will definitely influence visitors from other countries, we have to wait to see what happens but our incomes are going to be less", she told Xinhua.
The amendment does not revoke other existing general licenses for specific categories of Cuba travel, including the authorization at 31 C.F.R. 515.565 (a) for certain educational activities and related travel conducted under the auspices of accredited USA graduate or undergraduate degree-granting academic institutions.
The US government announced major new restrictions on US citizens who want to travel to the island and is limiting the most popular method of visiting.
Ensure that their method of travel is authorized - under the Department of Commerce amendment, those planning to visit Cuba by cruise ship or private jet may be compelled to switch to commercial aircraft.
"I think it will greatly affect the Cuban nationals", said Thomas. The "individual" P2P (not requiring to be organized by an organization that is a person subject to US jurisdiction) had been eliminated as of November 9, 2017.
"So far we have only had one person cancel their cruise, but he is actually taking another one", said Maria Thomas, owner/CEO of Lakeland-based Dreamward Travel.