This is also the first time since 1983 that two unseeded women's singles players have reached the semi-finals of the French Open.
Anisimova, the first player born in the 2000s to reach the last eight or semi-finals at a Grand Slam, put up a great fight to save five match points but Barty sealed the win on her sixth in light drizzle.
"I haven't played against her", Barty said.
Having found her range and her speed, Anisimova rallied back and snatched the extra break to serve for the set at 6-5, only for Barty to force a tiebreak when the American buried a backhand into the net. I feel like I've played some really good tennis, some consistent tennis.
American teen Amanda Anisimova watched her magical run at Roland-Garros end in a three-set setback to Ashleigh Barty in the 2019 French Open semifinals on Friday in Paris. Now, she's strung together five nice wins. "Oh, it's incredible", she said.
"I just played the best tennis of my life".
Defeat will be tough to take for Anisimova, the 17-year-old looking to become the youngest finalist at a grand slam event since her childhood idol Maria Sharapova won Wimbledon in 2004 and the youngest in Paris since Martina Hingis in 1997.More news: Ubisoft is launching its own subscription service called Uplay+
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But her defeat formula there are no longer any Huge Slam champions left in the girls folks's plan and ensures that Saturday's victor would be the ninth diversified Huge Slam champion in the last 10 majors.
"Even though that level wasn't there for the whole match today, it was there when I needed it".
This year, the women's semi-finals matches were scheduled to be played on the main show court, the 15,225-capacity Court Philippe Chatrier, on Thursday.
It is a completely different situation in the men's tournament, where victories for Novak Djokovic and Dominic Thiem meant the top four seeds are all through to the last four.
Should Ms Barty triumph tonight, she will become the second Indigenous player ever to raise the Coupe Suzanne Lenglen since Evonne Goolagong Cawley in 1971 and the first Australian since Margaret Court in 1973.
But Barty rejected the notion that these results made things easier for her, whilst praising the strength of her competition.
"It was cold and windy and I can't wait to enjoy it, it's been an incredible journey I have been on and I can't wait until tomorrow".