Images of the Prime Minister breaking down in tears as she told how it had been "the honour of my life" to serve as leader fill the fronts of the Daily Mail, the Daily Mirror, the Daily Express and The Sun.
A new Prime Minister will be in place by mid-July after a fast track Tory election campaign was set out following Theresa's May's tearful announcement yesterday that her turbulent reign will end on 7 June.
If Britain's new prime minister - whoever it is - was willing to exit the bloc without a deal, it is unclear if Parliament would have the power to stop the move, according to constitutional scholars.
In January, he put forward the so-called Brady amendment to the Brexit deal, which called for the controversial Irish backstop to be replaced by "alternative arrangements".
Her fourth bid to get MPs to agree to her European Union divorce deal, this time with changes seeking to woo the opposition, went too far for many key cabinet members and her last remaining authority had all but evaporated.
On Wednesday evening Leader of the House of Commons Angela Leadsom announced her resignation from the cabinet, saying she no longer believed the government approach could deliver Brexit.
While parliament repeatedly rejected May's accord, lawmakers have also previously voted against leaving without any deal.
The issue is set to dominate the contest which will begin in the week of June 10 when Conservative lawmakers begin to whittle down the field before party members choose the victor from the final two candidates.
"I do so with no ill will, but with enormous and enduring gratitude to have had the opportunity to serve the country I love".
The next prime minister of the United Kingdom, a country of more than 66 million people, will be decided by the 100,000 or so paid-up members of the Conservative Party.More news: Audi culls TT coupe as electric shift hits combustion-era icon
More news: More rain and storm chances to finish off Memorial Day weekend
More news: Fed's Daly sees inflation moving back up to 2% target
Mr Hancock said he was running for leader because the party needed to look to the future and attract younger voters.
Politicians in her party and overseas paid tribute to her determination.
"The coming leadership election within the Conservative Party has the potential to further destabilise the Brexit process".
All the leadership contenders have strived to make their position on Brexit clear to their electors - the 313 Tory MPs who choose a shortlist and the 124.000 party members who will have the final say.
At the same time May told her local party branch that she would stay on in parliament and remain a MP.
International Development Secretary Rory Stewart is also positioning himself as a more consensus seeking alternative to Johnson.
It will be the first time Conservative members have directly elected a prime minister, as opposed to a leader of the opposition.