When these teams met earlier in the season, Chelsea recorded a 1-1 draw in the Premier League and a 2-1 win in the League Cup.
"Sometimes it doesn't work that well, because the competition is tough and the opponents are good".
Jurgen Klopp's Liverpool now lead the Premier League by two points from title rivals City, though the Merseyside club have played a game more than Pep Guardiola's side. We had two days to rest and they had six.
Guardiola, 48, said: "You have to have a special energy and I think at 71 - except Roy Hodgson - the others can not do it".
But speaking before the game, Chelsea winger Eden Hazard has made it clear that the Blues are only focusing on the game and now what happens with the title challenge. "After the penalty, Sergio reacted incredibly well and was mentally strong and the team was stable".
"We thought of more of a low game, with more passes and more control to attack in the right moment. We know what we are playing for and we are going to prepare well", added Guardiola.More news: 'Avengers: Endgame' Clip: Surviving Superheroes Split Up to Beat Thanos
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"Unfortunately, we could not score a goal but have a second leg with our fans at home and we'll be in the semi-finals". I like when they express what they believe.
With Liverpool keeping pace at the top, Man City can't afford a slip on on the road, but Roy Hodgson and his side will be hoping to pick up at least a point at Selhurst Park.
"They are really well organised, and up front, they have quality players".
Guardiola also called for the performance to be viewed within the context of City's relentless form over the past two seasons.
Sky Sports Main Event (Sky channel 401, Sky HD 855, Virgin channel 511) and Sky Sports Premier League (Sky channel 402, Sky HD 856, Virgin channel 512) will air coverage of the game from 2pm.