Scholes' departing statement is at odds with owner Abdallah Lemsagam saying upon his appointment in February that "Paul will have my backing 100 per cent".
Oldham have confirmed Scholes resigned from his position.
Ole Gunnar Solskjaer has left the door open to Paul Scholes at Manchester United following his resignation as Oldham Athletic manager.
"It is with great regret that I have chose to leave the club with immediate effect", Scholes said in a statement.
The 44-year-old is a boyhood Latics fan, but has endured a poor start to his managerial career with the club, winning just one of the seven games for which he was in charge.
According to Sky Sports, Scholes will be unveiled to the club fans the same day after which he will hold his first press conference. I personally was always supportive of any decisions Paul made or consulted me on reassuring him that he was the man in charge. I was content to remain in League Two for this season and working with the team we have for the remainder of this season is important.More news: James knocks out Bulls but Lakers still a long shot
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Oldham were relegated from League One last season, and now sit in 14th place in the table.
"Management is a hard job and we would have worked with Paul to find solutions, had we been given the chance". I personally believed that he would be the manager to take us forward this season and next and I know many of you felt the same.
"I hoped to at the very least, see out my initial term of 18 months as the manager of a club I've supported all my life", he said.
"We wish him well and thank him for his contribution".
But Lemsagam said he was "surprised by the reasons" that the former Manchester United midfielder has given.