Officers accompanied investigators with the Children's Division of the Missouri Department of Social Services when they found the three girls and one boy between the ages of 5 and 12 in a Farmington home, the publication reported.
Andrew Joseph Fabila and Paige Isabow Harkings, both 24, were charged with four counts of criminal child endangerment, Wise County jail records showed.
Their parents, David and Louise Turpin, were arrested shortly after and charged with almost 50 counts of child abuse, torture and false imprisonment.
Akin said the children were starving and that a plentiful supply of food had been locked inside cabinets and a refrigerator in the barn. The two oldest children were locked inside of a dog cage.
Four young children who appeared malnourished and were covered in fecal matter, including two locked in a dog kennel, were found at a Texas home, leading to the arrest of two adults on accusations of child endangerment.
The children were taken to Cook Children's Medical Centre in Fort Worth, but a hospital spokeswoman declined to disclose their conditions.
Authorities say they responded to a home in the city northwest of Fort Worth in regards to possible domestic violence between two people at around 7 a.m. Tuesday.More news: The end has finally come for NASA's Opportunity Mars rover
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"This is at the top of the list of worst cases, as far as children", Johnson said, calling the use of the dog crate and lack of care "unacceptable".
Neighbors told CBS 11 the couple may have been on the property for three or four weeks, but they had never seen any signs of children living there. Deputies fed the kids and gave them water before taking them to the hospital, according to the sheriff's office.
The woman is the mother of all four children and the man is father of one of them, Akin told the newspaper.
According to Sheriff Lane Akin, the man's face was covered in scratches when authorities arrived on the scene.
'They were positioned in a manner where those small children would not have access.
"You'd think that being right across the street we would know something", she said.