The tiger was found in Houston in the Harrisburgh/Manchester area of the city.
Jason Alderete told KTRK-TV that the person who called 311 was asked if they were under the effects of drugs or actually saw a tiger.
Houston police obtained a warrant to enter the home and on Monday, BARC animal enforcement officers retrieved the tiger, the shelter said in a Facebook post.
The home had been abandoned for some time, Alderete said.
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"We made arrangements for the tiger to be transferred to another facility that is licensed to handle exotic pets", said Heidi Krahn, executive director of the Center for Animal Research & Education.
News of the tiger has created quite a buzz on social media, and reactions have even been curated into their own Twitter Moment titled "Overweight tiger found in abandoned USA home".
The tiger was tranquilized in order to move it out of the house, officials said. "Very, very rarely do we take in a tiger". "It's just finding the right combination and then transporting", Cottingham said.
Houston Zoo said in a statement that it would not be able to take the tiger.
An anonymous tip from a "concerned citizen" led to the discovery of a tiger at a vacant home in Houston, Texas, US.
The cage that kept the animal was not large or sturdy enough to hold the tiger, the station reported.