Little has improved after former player and Real Madrid B coach Santiago Solari took over too, as club chairman Florentino Perez grapples with an aging squad and the next managerial appointment.
Isco and Asensio: "A year ago, Isco and Asensio were the great sources of hope at Real Madrid; [now] one has lost his way and the jury is out on the other".
"After the tests carried out on our player Karim Benzema by the Real Madrid medical services, he has been diagnosed with a fracture in the phalanx of the fifth finger in the right hand", a statement read.
The hard injury situation comes as Madrid have nine games in the next month, running up to a La Liga clash with Atletico Madrid on February 9 or 10 and the Champions League round of 16 first leg at Ajax on February 13.
Vinicius had another opportunity to double the lead for Solari's men on the half-hour mark with a low strike across the face of goal that was smothered by Lopez at the near post.More news: Game of Thrones Final Season Premiere Date Revealed
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Madrid now sit in fourth place in La Liga after 19 matches played on 33 points - ten adrift of bitter rivals Barcelona who top the pile.
Vinicius: "He ups the pace of Madrid's play, and whenever he receives the ball they look more unsafe".
Madrid's long absentee list, which included Gareth Bale, Marco Asensio, Thibaut Courtois and Toni Kroos, prompted Solari to field an unorthodox 3-5-2 formation but the Argentine again opted to leave out fan favourite Isco and also dropped the experienced Marcelo.
"I am not the one who should give advice to Isco, a footballer who has played for many seasons in Spain's top division". "There is nothing personal involved".
"We're very sad to not even have got a draw, we deserved to get a better result", said Betis coach Quique Setien. "They can all play, they are all part of the squad".