"We would be victims of aggression and would get to Heavens as martyrs", he said, adding those who would launch the strike would "just die and not even have time to repent".
Russian President Vladimir Putin has called the deadly shooting and bomb attack by a teenager in Crimea a "result of globalization" and says that adults are failing to offer young people an alternative to an outburst of violence.
"The Islamic State was controlling the camp for three hours and took the people hostage from the camp to inside the ISIS area", he said.
"The aggressor should know that retaliation is inevitable", he told an global policy forum in Sochi.
The new hypersonic missiles could evade western defence systems.
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Another new weapon, the Avangard, is set to enter service in the next few months, he said.
His blunt talk on nuclear weapons comes as Russia's relations with the West remain tense over such issues as the wars in eastern Ukraine and Syria and allegations of Russian meddling in elections.
The leader said the situation in Syria remains hard, especially in the east of Euphrates, where USA and European Union citizens were among 700 people taken hostage by Daesh. Putin spoke on a wide range of topics from USA domestic politics to Russian involvement in Syria.
Putin said Thursday that Russian Federation helped negotiate the pullback of Iranian forces from the border with Israel over the summer.
Russia has beefed up its arsenals amid tensions with the West over the Ukrainian crisis, the war in Syria and the allegations of Russian meddling in the USA 2016 presidential vote. "An empire always thinks that it's so powerful that it can afford some mistakes and extra costs".