Mane's injury as reported in the Mail also comes after Virgil van Dijk was sent home by Holland because of a rib issue the defender hasn't been able to shake off since being substituted at Southampton.
Liverpool are still battling to cope with the news of Mohamed Salah who returned to the club with a muscle injury.
Van Dijk, who scored the opening goal for his country as they beat rivals Germany 3-0 in Amsterdam on Saturday, suffered a rib injury before Liverpool's Champions League win over Paris Saint-Germain last month.
Netherlands boss Ronaldo Koeman has already indicated the injury is not a serious one, but revealed that the centre-back would not play against Belgium on Tuesday night.
'The medical staff of the Dutch national team spoke to the medical staff of Liverpool and made the decision that he was playing only the Germany game and then after back to Liverpool. "He takes a rest".More news: Russia promises tough response to Ecumenical Patriachate over Ukraine
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The Reds trio have all been suffering with various injuries, with Van Dijk and Salah picking up issues during worldwide match.
James Milner, who was forced off with a hamstring injury against City immediately before the worldwide break, is the main doubt for the game at the John Smith's Stadium.
He has been struggling with the injury in recent weeks and it has been decided he will sit out the encounter.