Just as importantly for the home team, key midfielder Dele Alli is also expected to miss the match against the Reds, after picking up a hamstring injury with England.
Spurs had won their opening three league fixtures before the Watford reverse and Mauricio Pochettino's side are fifth ahead of the visit of early leaders Liverpool.
World Cup-winning France goalkeeper Hugo Lloris has been fined 50,000 pounds ($65,000) and banned from driving for 20 months for drunk driving.
Goalkeeper and captain Hugo Lloris will miss the match, just as he did prior to the global break, after suffering a thigh strain.More news: Senate Judiciary Committee schedules vote on Kavanaugh nomination
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Tottenham's preparation for a game against a Liverpool side boasting a 100 percent record so far has not been ideal.
Shaqiri said to the Daily Mirror: "He wants that we work hard - always - on the pitch".
Sky Sports pundit Merson insists that Liverpool's threat on the counter could be the difference between the two sides and he can see Jurgen Klopp's side continuing their flawless start to the season.
"You need to deserve to win and perform in the way that you believe you can beat your opponent".
Barnes said in an interview with the Daily Star: "What's good now is Liverpool, with the harmony and the fact Klopp's there and everybody loves him, the trust in him and the way the team's playing, that's all I'm interested in".
There's been talk about Harry Kane "struggling" but what do people expect him to do? Fly?