One of the quartet will take the armband in Monday's (AEST) Premier League opener against Manchester City, given Koscielny remains sidelined with the ankle injury that ruled him out of France's triumphant FIFA World Cup campaign.
Unai Emery may have found a radical solution to Arsenal's left-back conundrum after revealing England forward Danny Welbeck has been training in the role.
The England forward was outstanding despite having been back in training for less than a week after his exertions in Russian Federation and scored the opening goal as Arsenal, under new management, were swept aside at the Emirates. With Sead Kolasinac's knee injury keeping him out of action for the next two months, Nacho Monreal is the natural replacement for the Bosnian.
Another problem area is the left-back slot.
With Laurent Koscielny out for the foreseeable future, Sokratis Papastathopoulos is likely to make his Arsenal debut alongside Shkodran Mustafi at the heart of the defence. Hector Bellerin, meanwhile, will need all his speed against Leroy Sane.More news: Polansky falls to Djokovic in Toronto
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Here's how to watch Manchester City vs. Arsenal online.
David Silva could be a question mark for Sunday's fixture as well.
Sterling proved to be City's creative fulcrum, but he was fortunate to escape with a yellow card for a studs-up foul on Arsenal debutant Matteo Guendouzi in the early stages.
Throughout preseason, Emery stressed he wants to introduce a more aggressive approach to The Gunners way of attacking the opposition, it starts from pressing the opposition right from their 18-yard box.
The City boss said: "If you judge the players in the World Cup if they score a goal or not..."
Whether he partners up with Alexandre Lacazette or plays in front of Mesut Ozil and Henrikh Mkhitaryan, the striker will have chances in front of Ederson's goal. Kyle Walker will overlap more for City than for England, where he was shifted inside into a back three.
Somewhat criticised of Wenger in his latter stages of the Arsenal tenure is the lack of tactical preparation he gave to his team ahead of a big fixture against their rivals.