Guice injured his left knee at the end of a first-quarter run in Thursday's preseason opener against the New England Patriots. The initial thought was a sprained MCL, suggesting he'd miss a few weeks.
Several scouts had questioned Guice's durability going into the draft. He played all 16 games last season and earned NFL MVP honors after tossing 4,577 passing yards and 32 touchdowns.
Instead, Guice's National Football League career starts with a medical redshirt.
In camp, Guice had been splitting first-team carries with Kelley and Samaje Perine.
We know Chris Thompson figures to be a big part of the backfield workforce, but he's also coming off a season-ending injury a year ago with a fractured right fibula Other candidates include Byron Marshall or Kapri Bibbs, who have some big-play ability.More news: Bethenny Frankel's Boyfriend Found Dead in Trump Tower Home
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The former LSU star was fourth on the Redskins' depth chart at running back, but was expected to have a significant role this season.
Perine had been mentioned as a possible cut earlier this summer, and while that's unlikely to happen now, it should give us an idea as to what the coaching staff thinks of him. After providing some fantasy value two seasons ago, he turned in 62 mostly uninspiring carries past year, running for 194 yards and three touchdowns.
If anyone is a victor from a fantasy perspective here, it's Alex Smith.