And on Thursday, Yvonne Strahovski landed her first Emmy nomination for the role.
Bruce Miller, executive producer of "The Handmaid's Tale", acknowledged that the show's vision of a theocracy where women are treated as property was hard to watch.
Alison Brie was also a notable oversight for her standout work in "GLOW", the Netflix period female-wrestling comedy, as was "Modern Family", although after its glittering streak of Emmy nominations, it's hard to fault anyone for concluding the ABC sitcom's best days are behind it, especially with so many worthy newcomers to accommodate.
The "This is Us" star, who plays mom Rebecca Pearson on the hit NBC tearjerker, wasn't among the names included in the "Outstanding Actress in a Drama Series" category.
HBO, which was recently acquired by wireless carrier AT&T Inc, had 108 nominations, and noted in a statement that it was the eighth year it had gathered 100 nominations or more.
On the comedy side, last year's victor, Donald Glover for "Atlanta", goes up against Anthony Anderson, "black-ish"; Ted Danson, "The Good Place"; Larry David, "Curb Your Enthusiasm"; Bill Hader, "Barry"; and William H. Macy, "Shameless".More news: Astros option Ken Giles to Triple-A Fresno
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She earned a nomination herself for Outstanding Supporting Actress in a Drama Series a year ago.
The streamer's historical limited series, "The Looming Tower", on the other hand, picked up four nominations, including Jeff Daniels for lead actor in a limited series or movie, casting, directing (Craig Zisk), and supporting actor in a limited series or movie (Michael Stuhlbarg).
The 70 annual Emmy Awards air September 17 on NBC.
In the comedy categories, hip-hop themed FX show "Atlanta" is up against Amazon's (AMZN.O) "The Marvelous Mrs. Maisel", ABC's (DIS.N) "black-ish", "GLOW", "Curb Your Enthusiasm", quirky comedy "Barry", tech comedy "Silicon Valley" and "Unbreakable Kimmy Schmidt". It's a steep fall-off from there, although 13 networks or services garnered 10 or more nominations, reflecting the breadth of competition that now characterizes the Emmy race in the age of "peak TV".