Fury extended his unbeaten record to 26 wins, 19 by knockout, while Seferi suffered his second defeat in 25 fights.
Both Fury and promoter Frank Warren admitted that they were disappointed in Seferi's inability to answer the bell for the fifth round but neither are under any illusions about the plan to ease the former world heavyweight champion back into the fight game. I will be better next time.
"He didn't come to fight, he came to run around the ring", Fury told a press conference.
Seferi quit on his stool at the end of the fourth round, and Fury announced he would soon be back in the ring.
"I'm sure Frank Warren is going to keep me busy and the calibre of opponents will keep rising", Fury said.
"I learned that two and a half years out of the ring was a long time".
"I opted for a bigger opponent but we couldn't really get anybody, there was nobody available".More news: Kitchen towels can cause food poisoning
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Seferi is 39, has not boxed at an elite level, was 7 inches smaller and almost 70 pounds lighter than Fury.
The difference in weight between the fury and the Sefer was nearly 30 kg, whereas the difference in height - 26 cm in such hands equal match could not be, but as it turned out, the Manchester Boxing was not at all.
Fury's next fight will reportedly be on the undercard of Carl Frampton's headline show at Windsor Park on 18 August.
It was not always pretty from Fury, but it allowed the 6ft 9in Englishman to shed some of the ring rust before moving on to harder tests.
Germany's Manuel Charr, who holds the secondary WBA title, is one potential opponent for Fury in the next six months.
Joshua and Deontay Wilder, the American who holds the World Boxing Council (WBC) belt, remain distant targets for Fury as they are in talks to face each other.
Just boxing again was an achievement for Fury, whose life span out of control after ending Klitschko's nine-and-half year reign. Fury then piled on the pounds - he claimed to have lost eight stones in preparation for Seferi - and served a backdated drugs ban for testing positive for a banned steroid in February 2015.