The final 23-man squads for the 2018 World Cup are being announced on June (deadline is 11 a.m. ET) and there have been plenty of surprises so far.
Neuer made the squad despite playing in just one official game, a friendly against Austria on Friday, since breaking a bone in his foot in September but talented 22-year-old Sane was the biggest name to miss out.
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Marco Reus' return to fitness and Low's preference for Brandt - who had been expected to miss out - have seen him edged out, while Low is also a big fan of Julian Draxler, who offers greater flexibility, able to also play in the left-sided role Sane covets - and was player of the tournament in Russian Federation last summer.
"It was a very tight decision between him and Julian Brandt (of Bayer Leverkusen) which went in favour of Brandt", Low said. "Leroy has a huge talent", Low told reporters. "If it was a 100 metre race, it would have been a photo finish".