Earlier this month, Israel bombed Iranian military positions in Syria in what it said was retaliation for Iranian strikes on the occupied Golan Heights.
"One of our military airports in the central region was exposed to hostile missile aggression, and our air defense systems confronted the attack and prevented it from achieving its aim", state news agency SANA said.
According to earlier reports by the agency, explosions had been heard near the al-Dabaa military airport.
Syrian state media did not comment on the origin of the missile attack.
Syrian state-run media have reported that government aircraft have dropped leaflets on terrorist-held areas in Deraa urging fighters to disarm.
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A war monitor, the Syrian Observatory for Human Rights, reported two waves of US -led missile attacks early Thursday it said targeted areas controlled by IS east of the Euphrates River. It had no information on casualties.
A war monitor, the Britain-based Syrian Observatory for Human Rights, reported on Wednesday that Syrian government forces fresh from their victory this week against an ISIS pocket in south Damascus were moving into the southern province of Deraa.
On Friday, the US State Department said in a statement it was concerned by the reports of an impending government operation in the area and warned Syria not to escalate the conflict. He said the 12 pro-regime fighters killed were not Syrians, but he could not provide more details on their identity.
"We have no operational reporting of a US-led coalition strike against pro-Syrian regime targets or forces", Captain Bill Urban, a spokesman for US Central Command, told Reuters.
"Some of our military sites between Albu Kamal and Hamimia were exposed at dawn today to aggression launched by USA coalition jets", state news agency SANA reported, citing a military source.