Faltings said first responders appeared to have removed the children from the scene. A red dump truck with a mangled front end was parked along the highway nearby, about 50 miles (80 kilometers) west of NY.
"Our hearts are broken by today's tragedy", Gov. Phil Murphy said in a Facebook post after arriving at the school.
The Morris County Prosecutor's Office in New Jersey has confirmed that there have been some deaths following a school bus crash on Interstate 80 in Mount Olive. It's unclear what number of college students have been aboard the bus or the variety of automobiles concerned within the collision.
Mount Olive Mayor Rob Greenbaum, who saw the aftermath of the highway crash from an overpass, described the scene as "horrific".More news: Senate votes to protect net neutrality rules
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New Jersey State Police tweeted the legislation enforcement company was investigating a "severe" motorcar accident involving a college bus and dump truck.
At least two canine units were searching the woods along the roadside Thursday afternoon, but it wasn't clear why.
At least two of the victims have been sent to St. Joseph's Medical Center in Paterson. He told HLN Thursday there were possible ejections in the crash. "I believe both patients are schoolchildren", she said. "The kids were obviously freaked out".
A sign outside of the school, about 50 miles (80 kilometers) from the crash site, informed people to go to the auditorium for updates on the accident and the school was offering crisis counseling. A school district official said its superintendent was preparing a statement.
More information will be provided as it becomes available.