Antibiotics May Raise the Risk for Kidney Stones

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Antibiotics could increase the risk of painful kidney stones.

Tasian along with his fellow mates is planning to go for full proof investigation of microbiomes in the children and adolescent's body in the near future. "The reasons for the increase are unknown, but our findings suggest that oral antibiotics play a role, especially given that children are prescribed antibiotics at higher rates than adults", said co-author Michelle Denburg from CHOP.

A groundbreaking new study is the first to link the use of antibiotics to kidney stones.

According to Gregory E. Tasian who is a pediatric urologist and the leader of this research, the entire prevalence regarding kidney stones has seen an increase of around 70% in the last 30 years.

"Everyone thinks you're older when you get them, so no one believed it when I said I had kidney stones", said Gaal.

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The study, in the Journal of the American Society of Nephrology, used health records of 13.8 million patients of general practitioners in Britain. For the study, the team analysed prior antibiotic exposure for almost 26,000 patients with kidney stones, compared to almost 260,000 control subjects.

After adjusting for mitigating factors such as other medication use and being diagnosed with a urinary tract infection, diabetes or gout, they found that sulfas, cephalosporins, fluoroquinolones, nitrofurantoin/methenamine and broad-spectrum penicillins were all associated with a heightened risk of kidney stones, when taken three to 12 months before diagnosis. "So if they were prescribed at, say, 15 years of age, the risk was much higher than if it was prescribed later in life", said Dr. Tasian.

Those who received sulfa antibiotics were twice as likely as people in the control group to develop kidney stones, while individuals who received broad-spectrum penicillins were 27 percent more likely.

It's estimated that about 30 percent of antibiotic prescriptions are inappropriate. "A change in prescribing patterns might decrease the current epidemic of kidney stones in children".

Tasian and his colleagues are hoping to expand this research into broader, population-based studies to better understand how variations in microbiome composition may influence the development of kidney stones.

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