The new People's Vote campaign has been launched in the United Kingdom, pushing for a separate referendum to ratify or reject the final Brexit deal.
Tory MP Peter Bone, a leading Leave supporter, said: "This call for a second referendum is so off the planet that I suppose it is appropriate to have someone from Star Trek involved".
Sir Patrick claimed the characters in his most famous screen roles, Star Trek's Captain Jean-Luc Picard and Charles Xavier from the X-Men, would have supported Britain's European Union membership.
The campaign brings together Open Britain along with the European Movement and another seven organisations that collectively claim to have more than 700,000 supporters, 20,000 activists, and more than a million followers on social media.
The former minister added: 'I think the best and right thing to do is to put it back to the people and say, you can have a vote on this deal'.
"Brexit is not inevitable".
Appearing alongside Mr Umunna on ITV's Peston on Sunday, she said: "A second referendum, Chukka, which is what you're really campaigning for, is never going to happen".More news: Barry Lewis: Facebook and the illusion of privacy
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"Brexit will affect everybody in the country, which is why it should not be left to 650 politicians to decide our future but 65 million people".
Another one of those attending was Green Party MP and co-leader Caroline Lucas. The organizers suggest that the 2016 referendum on Brexit should not be taken as final. "We're now trying to deliver on that mandate from the people".
"And we must continue to work together to build further upon this solid foundation by building on our existing trade links and establishing new ones".
Sir Patrick, Emeritus Chancellor at the University of Huddersfield, told the BBC that if people voted to reject the exit deal, the United Kingdom would "simply stay" in the EU.
Chuka Umunna, MP for Lambeth, which had the highest Remain vote in the country, said: "We need more Conservative members of Parliament to be as courageous as Anna and many others who defied the whip and put their country before their party".
But he added: 'As time has gone by, the information that we are receiving about the terms and conditions of that separation are quite unlike the terms and conditions that were spoken of so loosely during the 2016 campaign'.