US President Donald Trump also accused Russian Federation and Iran of aiding Syrian President Bashar Assad and promised to make a decision within 48 hours on his response to the alleged chemical weapons attack, threatening to launch "nice and new" missiles at Syria.
Western powers continued to weigh their options on Friday over possible strikes against Syria's regime as pressure built to avoid an escalation following a warning from Russian Federation that military action could lead to "war".
"The worst apprehensions have true", ambassador Anatoly Antonov said in a statement.
"Russia convenes an emergency meeting of the UN Security Council to discuss aggressive actions of the U.S. and its allies", President Vladimir Putin said in a statement published on the Kremlin website.
Moscow, he said, has "irrefutable information that it was another fabrication".
The Ministry claims the air strikes were a response to the "success" of Al Assad's Syrian army in liberating their territory from global terrorism.
The UN Security Council is to meet again on Friday, at Russia's request, to try to defuse the standoff, as United States President Donald Trump appeared to back away from imminent action, days after warning Russian Federation to "get ready" for missile strikes.
A day before a team from the global chemical weapons watchdog was to arrive in Douma, just east of Damascus, Russian Defense Ministry spokesman Maj.More news: This is our proudest victory, says Vincent Kompany
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Putin responded to Saturday's attack by calling the strikes "an act of aggression against a sovereign state that is at the forefront of the fight against terrorism".
"In 2013, President [Vladimir] Putin and his government promised the world that they would guarantee the elimination of Syria's chemical weapons", Trump said.
On Thursday, Trump held a meeting with his national security team, but White House officials say no final decisions have been made.
In response to the alleged poison gas attack in the town of Douma that killed dozens of civilians last week, the strike was aimed at cutting off chemical weapons production in Syria.
Speaking to reporters in Moscow, he reiterated warnings to the West against military action in Syria, saying any such "adventures" in Syria would increase flows of refugees into Europe.
The ministry also pointed at previous use of chemicals by rebels in fighting with Syrian government troops.
The US "specifically identified" targets to "mitigate the risk of Russian forces being involved", Dunford said.