According to the Phoenix Fire Department, the house is located near McDowell Road and 69th Avenue.
Crews arrived to find heavy fire showing throughout the right-side of a split-level, wood-frame house.
At the height of the fire, more than fifty firefighters were at the scene from several area fire departments.
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Rutledge said firefighters continued to search for the man's wife who was believed to be unaccounted for at the time.
The cause of the fire was not immediately determined, but it was not considered suspicious, Galm said.
Crews remained on the scene for several hours to ensure the fire was out.