Two-time Olympic champion Mikaela Shiffrin can clinch her second overall world cup title with strong performances this week in Ofterschwang, Germany.
The American's only remaining challenger, Petra Vlhova, needs a win or second place to maintain a slim chance of overtaking Shiffrin in the slalom standings but the Slovak skier was 0.65 behind in sixth.
Her nearest rival, Wendy Holdener of Switzerland, lost any hope of overhauling the United States star when she trailed in 14th on Friday.
Shiffrin won slalom gold at the 2014 Sochi Olympics at the age of 18, a year after she won the first of her three consecutive world slalom titles.
The Norwegian won Olympic silver medals in both giant slalom and downhill last month but called her first career World Cup win "the best feeling there is".
Austrian legend Annemarie Moser-Proell won her 41st race at age 21, then took a whole season off to care for her father before he died of lung cancer in 1976.
The World Cup continues on Saturday with a slalom in Ofterschwang, followed by one race each of every discipline at the World Cup Finals in Are, Sweden.More news: Trump pardons Navy man who shot illegal sub photos
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"My biggest challenge this year has not been the Olympics or the (World Cup) overall or any of that, but getting motivated for these last races", Shiffrin said.
The American duly wins for the second successive season with five races still remaining.
"It's an incredible moment right now", Shiffrin said.
Friday's result stretched Rebensburg's lead over Shiffrin to 101 points, leaving the American out of contention for the GS title.
Tessa Worley of France finished 13th today but still leads the giant slalom World Cup standings with 663 points. "But nothing is impossible so I am going to stay focused".
Shiffrin sits second, on 657, and Rebensburg third on 607.
Up next, the women compete in a slalom Saturday in Ofterschwang.