Anthony Martial is back and Zlatan Ibrahimovic trained with his United team-mates ahead of the match, but Ander Herrera, Marcos Rojo, Phil Jones and Daley Blind remain sidelined.
However, since the Sevilla draw, United have found the winning momentum back with two incredible comebacks against Chelsea and Crystal Palace in the Premier League, followed by a 2-1 victory at Old Trafford against arch-rivals Liverpool. "So, of course, knockout becomes more important than league matches". I know that it is very hard to go through.
The first leg ended in a goalless stalemate in Spain, and while the Andalusians will be disappointed not to make home advantage count, their Italian manager believes they can progress by completing one simple task.More news: Catch a Louisiana high school senior on American Idol
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United go into the clash with the Spanish side following a morale boosting win over the Reds that put them in pole position to secure second position in the English Premier League behind Manchester City.
"I think when a team gets into the last eight the feeling is you are [competing] among the best but anything can happen".
Three-time European champions, United have made the Champions League quarter-finals just once in the past seven years.
Sevilla were eliminated at this stage a year ago by Leicester City and they are the underdogs ahead of their first ever competitive match at Old Trafford.