20-times Grand Slam victor Federer is chasing a sixth title at the event, and will take some stop judging by the manner in which he swatted aside his 26-year-old opponent in only 58 minutes. "I made so many unforced errors that it was just one of those exdays where you are not able to find the rhythm from the baseline especially from the backhand side". He had surgery in Switzerland shortly after that.
"It feels insane. I mean, I'm still in shock", Anisimova said.
Federer has already won two titles in 2018, claiming his 20th Grand Slam crown by winning the Australian Open in January.
But that was about as competitive as things got in the third-round match at the Indian Wells Tennis Garden on Monday.
He was unable to get past his opening match in Indian Wells on Sunday even after another extended break from the game he once dominated and after what he termed "a small medical intervention" on his troublesome right elbow. "That is as head scratching as anything you'll see".More news: YouTube is getting a dark theme for iOS and Android today
More news: European Union asks for more clarity from Britain on future relationship after Brexit
More news: Bus carrying Texas students plunges into Alabama ravine
In other action, current world No. 1 Roger Federer picked up where he left off, winning the four games he needed to defeat Federico Delbonis after their match was interrupted the night before by rain.
Kevin Anderson beat Nicholas Kicker 7-6 (1), 7-6 (3) while Tomas Berdych was defeated in straight sets by Chung Hyeon. Federer is looking to make it three in a row and maintain his place as ATP's top ranked men's singles player. Federer hit a running forehand passing shot to break at love and take the set 6-2. "The surface doesn't react so much; the ball doesn't travel so fast".
Yuki Bhambri of India pulled off a surprise when he toppled ninth-seeded Frenchman Lucas Pouille 6-4 6-4. That comes over playing a good schedule with the right amount of practice, vacation, matches, everything.
Former number one and tenth-seed Angelique Kerber rallied past Ekaterina Makarova 3-6, 6-4, 6-2 and Petra Martic upset last year's French Open champion Jelena Ostapenko 6-3, 6-3.
"To me, it's not that surprising", Federer said of Novak's loss.