The Spain worldwide had played every minute of the Gunners' Premier League campaign until he was not included in the starting line-up for Sunday's 2-1 Premier League defeat to Brighton and Hove Albion.
Bellerin was rested for the defeat at Brighton last weekend but developed an injury in training earlier this week and scans on Wednesday showed he had inflammation in his left knee.
Wenger gave fatigue as the reason he opted to leave Aaron Ramsey, Hector Bellerin and Danny Welbeck out of his starting line-up at south coast club Brighton's Amex Stadium and the veteran manager is hoping his decision means he can call on fresh legs at the San Siro. "It doesn't look a long-term problem", explained the manager in his Press conference.
"If I had listened to people who were talking about where I was going to be, I would not have been here".
At the time he said: "I've been here a long time and feel like this is my home; I am happy to be a Gunner for many more years". "I know it's not going to be easy, but we're trying, and doing our best". Players change their mind quickly.
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"We have (had) a bad period and did not have the results we wanted".
Wenger is under increasing pressure, and has told his players to forget about their recent struggles and focus on the simple things.
"We have to be realistic, we need two teams to collapse to qualify for the Champions League, and I don't see that happening".
He added: "The next manager coming in, whoever it is, thinks I've got three or four (players) I can hang my hat on, three or four they're my players for the next five years".
That streak was part of an 11-match winless run for Arsenal, and they would eventually finish the 1976-77 campaign eighth in the English First Division, per Soccerway, as well as reaching the fifth round of the FA Cup and the League Cup quarter-finals.
Former France striker Henry, who is now an assistant to Belgium coach Roberto Martinez, was asked on Sky Sports if he would take the Arsenal job should the opportunity arise. In life, you forget quickly how good you are.