Vonn finished a massive 0.96 seconds ahead of Tina Weirather of Liechtenstein and was 1.25 seconds ahead of American teammate Jacqueline Wiles on Thursday.
She raced a super-G at Cortina a year ago, finishing fourth, but skipped the downhill there.
Injuries have continually peppered the American's glittering career - she missed Sochi 2014 with a knee injury while decisions to compete are taken on a race to race basis - but Vonn proved she is still a force to be reckoned with.
She has been overshadowed by young teammate Mikaela Shiffrin in recent weeks but United States veteran Lindsey Vonn hit back with victory in Italy Saturday to reignite her Olympic hopes and move to within seven of the record of World Cup wins. After winning both downhill training runs this week, each by almost a full second, she posted the highest top speed in the race of nearly 84 miles per hour.
Lindsey Vonn amped up her Olympic preparations by winning a World Cup downhill by a large margin on Saturday at Cortina D'Ampezzo, Italy. She has now won back-to-back downhills this season.
"Last year, I had a pretty good super-G result, but to race in the downhill this year has been really exciting", Shiffrin said at the post-race news conference. "So it made me really happy just to be out there on the mountain today". Jackie Wiles (Aurora, Ore.) finished third and also punched her ticket to the 2018 Olympic Winter Games.More news: Sirius XM (SIRI) Stock Rating Lowered by JPMorgan Chase & Co
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Vonn's win sees her become the second skier, male or female, to win a World Cup race in 15 different calendar years, while she moves up to fifth in the downhill standings.
Vonn's USA teammate Jacqueline Wiles finished third, 0.98 behind, for her second career podium result.
"I learned a lot, to be aggressive and I can use that tomorrow", she added. "I'm really, really proud of her!"
At 33, Vonn became the oldest woman to win a World Cup downhill, beating the previous mark established by Elisabeth Goergl, an Austrian who was 32 when she won in 2014.
"For me good to get a good result to build my confidence and get a good result going into the Olympics", she continued.
Goggia, Vonn and Shiffrin all look like Olympic downhill medal contenders. "She's a great friend, and role model, and I'm super thrilled to be on the podium with her".