Undefeated Premier League leaders City head to Merseyside with a handsome 15-point advantage over Manchester United at the summit but history - along with Liverpool's own impressive run of 17 games unbeaten in all competitions - suggests they are in for a rough ride on Merseyside.
City last claimed victory at Anfield in May 2003, securing a 2-1 win thanks to former Liverpool striker Nicolas Anelka's late brace.
"Oxlade-Chamberlain is there, Lallana is back, but obviously you are going to miss Coutinho".
Liverpool are unbeaten in 14 league home matches against Manchester City, winning the last four in a row.
"We've still got tough teams to come", he said on Friday. We look at the stats behind the key battle at Anfield.More news: Heaps of New Games and Ports Revealed for Switch
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However, City boss Pep Guardiola is now optimistic the 20-year-old will return to his fold by the end of January or early February.
Guardiola, who is again set to be without captain Vincent Kompany due to a calf injury, believes the weekend clash will provide another stern examination of his team's big-game pedigree, having seen them pass such tests with flying colours at Stamford Bridge, Old Trafford and Napoli's Stadio San Paolo this term.
That form has helped propel Guardiola's side to the top of the Premier League and into the last 16 of the Champions League.
How many of Arsenal's Invincibles would make it into the current Manchester City side? According to Phil Neville, signing him from under City's noses would be an "unbelievable coup".
Which of these reported transfer targets would you like to see at Anfield?
Have your say on who Guardiola should bring to the Etihad Stadium.