And the first chance to prove that is at home to runaway Premier League leaders Manchester City on Sunday.
It would also give Klopp the option of deploying him behind Roberto Firmino in a 4-2-3-1 system, directly filling the gaping hole Coutinho has left and catering for the development of a suitable ecosystem for fellow attackers Sadio Mane and Mohammed Salah to thrive, occupying the wide roles.
"It's normal in the business".
"It is normal to lose players and buy players and you must always react". It is all about the atmosphere in the club.
In terms of the game tomorrow, I'll be very interested to see how Guardiola's team copes with man of the moment Mohamed Salah.
"I liked Phil, his behaviour was always fantastic". He's there, we are still here and we have to deal with the situation. Like Sterling, like Suarez.
"If there's somebody, maybe, who should be angry or massively disappointed - or whatever in this case - then it could be the manager of the club, but I'm not".
The Reds finally had to relinquish their hold on Coutinho earlier this week when the midfielder was finally granted his dream move to Barcelona.More news: The World Ends With You returns remixed on Nintendo Switch
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"But it was clear that's over now - he can not do that anymore so we made that decision".
While he acknowledged that it is "not too cool" that Coutinho has left, he says it is "not a real problem at all" because they will "bring in other players that's for sure", adding: "If we do it in this [January] window?"
"When Phil wasn't in the team we still played great football and we have still incredible players who can score goals - the likes of Mo [Salah], Sadio, Roberto". I just want him to be one of the best in the world and enjoy what he can do'. That's how it is.
"We only have to carry on". They tried. We want to do something quite similar. "We go with open eyes in this window but we won't do insane things". "Right [player] before expensive".
"The club tried everything to convince Phil to stay here", the manager said. "You have to accept it".
Brazilian Coutinho was unveiled as a Barcelona player on Monday, following his £145million move from Liverpool last weekend.
After putting pen to paper on a five-and-a-half-year deal at the Nou Camp, which will see him earn around £12m-a-year, Coutinho said: 'I'm very, very happy.