The auto, a white Nissan Altima, was driving at a high rate of speed and crossed three lanes of 17th street in Santa Ana, California, before hitting a median and going airborne.
A fire sparked in the building following the collision, but it was extinguished quickly. The vehicle hit the center divider and went airborne and landed into the building.
KTLA reported, citing local police, that the driver of the vehicle admitted to using narcotics before the crash.
Officials say a small fire injured one person who managed to get out of the auto unassisted. The vehicle then crashed into the second floor of a two-story building with a dentist office in it, according to Orange County Fire Authority.More news: Diana's favourite photographer Mario Testino accused of molesting string of male models
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The car's occupants both sustained minor injuries.
At 6.45am PST (2.45pm GMT) the fire department tweeted: "OCFA in Santa Ana with a vehicle that crashed into the second floor of a small Office building".
Fire crews were on hand to put out a brief fire to the building. "One person self extricated, the other person is still trapped in the vehicle".